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Micelles from polyethylene glycol/phosphatidylethanolamine conjugates for tumor drug delivery.

Publication Type:

Journal Article

Authors:

Lukyanov, Anatoly N; Gao, Zhonggao; Torchilin, Vladimir P

Source:

J Control Release, Volume 91, Issue 1-2, p.97-102 (2003)

Keywords:

Animals, Antineoplastic Agents, Drug Delivery Systems, Enzyme-Linked Immunosorbent Assay, Excipients, Female, Mice, Mice, Inbred C57BL, Micelles, Neoplasms, Particle Size, Phosphatidylethanolamines, Polyethylene Glycols, Solubility

Abstract:

<p>Micelles prepared from polyethylene glycols of various lengths conjugated with phosphatidylethanolamine (PEG-PE) were loaded with various poorly soluble anticancer agents. PEG-PE micelles selectively accumulated in Lewis lung carcinoma (LLC) tumors implanted in mice. Modification of the micelles with tumor specific antibodies further enhanced the efficiency of tumor accumulation.</p>