01753nas a2200265 4500008004100000022001400041245005500055210005400110260001300164300000900177490000800186520099400194653002801188653001601216653002401232653004101256653001401297653001101311653001901322653002001341100002301361700002001384700002301404856006001427 2002 eng d a0009-898100aMicrofluidic technologies in clinical diagnostics.0 aMicrofluidic technologies in clinical diagnostics c2002 Jul a1-100 v3213 a
BACKGROUND: Laboratory instrumentation and analytical devices are becoming smaller, simpler, and smarter. This trend to miniaturization extends to fluid handling and fluid analysis. However, fluid behavior undergoes significant changes as geometric scale decreases. The laminar flow behavior of fluids in microfluidic devices must be accommodated in the design and development of clinical and bio-clinical miniaturized systems.
CONCLUSION: The scale of chemical and clinical analysis systems will continue to decrease. The capability to manufacture smaller fluidic devices and to quantitatively monitor smaller volumes of liquids bring this process of miniaturization into the domain of laminar flow. New and enabling technologies are being developed using the unique diffusion-based characteristics of the laminar flow domain for sample preparation and analysis. These new analytical systems will have a significant impact on the future of clinical diagnostics.
10aBiomechanical Phenomena10aBody Fluids10aChemistry, Clinical10aChromatography, High Pressure Liquid10aDiffusion10aHumans10aMicrochemistry10aMiniaturization1 aSchulte, Thomas, H1 aBardell, Ron, L1 aWeigl, Bernhard, H uhttps://www.microfluidicsciences.com/drupal/?q=node/225