01280nas a2200169   4500008004100000245009200041210006900133260000800202520053900210100002200749700002400771700002200795700002500817700002400842700002000866856022400886       2012                        eng d00aUnited {States} {Patent}: 8163535 - {Devices} and processes for nucleic acid extraction0 aUnited States Patent 8163535 Devices and processes for nucleic a  capr3 aDevices, processes, and kits for the extraction of nucleic acids from biological samples are disclosed. The devices comprise a first port, a second port, and a binding chamber intermediate and in fluid communication with the first port and the second port. The binding chamber comprises an unmodified flat glass surface effective for binding a heterogeneous population of nucleic acids. The first port, second port, and binding chamber define a continuous fluid pathway that is essentially free of nucleic acid-specific binding sites.1 aReed, Michael, W.1 aNanassy, Oliver, Z.1 aHaydock, Paul, V.1 aSharma, Nigel, Rudra1 aBardell, Ronald, L.1 aHargrave, Perry  uhttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=%22Sharma%3B+Nigel%22.INNM.&OS=IN/%22Sharma;+Nigel%22&RS=IN/%22Sharma;+Nigel%2202044nas a2200169   4500008004100000245012100041210006900162260000800231520126200239100002501501700002701526700002101553700002401574700002201598700002401620856023001644       2010                        eng d00aUnited {States} {Patent}: 7648835 - {System} and method for heating, cooling and heat cycling on microfluidic device0 aUnited States Patent 7648835 System and method for heating cooli  cjan3 aAn integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.1 aBreidford, Wayne, L.1 aLancaster, Christy, A.1 aHayenga, Jon, W.1 aBardell, Ronald, L.1 aTonn, Jeffrey, F.1 aWeigl, Bernhard, H.  uhttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=9&f=G&l=50&co1=AND&d=PTXT&s1=%22Weigl%3B+Bernhard%22.INNM.&OS=IN/%22Weigl;+Bernhard%22&RS=IN/%22Weigl;+Bernhard%2202046nas a2200169   4500008004100000245012100041210006900162260000800231520126200239100002101501700002701522700002601549700002401575700002201599700002401621856023101645       2009                        eng d00aUnited {States} {Patent}: 7544506 - {System} and method for heating, cooling and heat cycling on microfluidic device0 aUnited States Patent 7544506 System and method for heating cooli  cjun3 aAn integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.1 aBreidford, Wayne1 aLancaster, Christy, A.1 aHayenga, Jon, Wallace1 aBardell, Ronald, L.1 aTonn, Jeffrey, F.1 aWeigl, Bernhard, H.  uhttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=11&f=G&l=50&co1=AND&d=PTXT&s1=%22Weigl%3B+Bernhard%22.INNM.&OS=IN/%22Weigl;+Bernhard%22&RS=IN/%22Weigl;+Bernhard%2200869nas a2200169   4500008004100000245012900041210006900170260000800239520009100247100002200338700002400360700002200384700002500406700002400431700002000455856022400475       2009                        eng d00aUnited {States} {Patent}: 7608399 - {Device} and method for extraction and analysis of nucleic acids from biological samples0 aUnited States Patent 7608399 Device and method for extraction an  coct3 aDevice and methods for extracting and analyzing nucleic acids from biological samples.1 aReed, Michael, W.1 aNanassy, Oliver, Z.1 aHaydock, Paul, V.1 aSharma, Nigel, Rudra1 aBardell, Ronald, L.1 aHargrave, Perry  uhttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=2&f=G&l=50&co1=AND&d=PTXT&s1=%22Sharma%3B+Nigel%22.INNM.&OS=IN/%22Sharma;+Nigel%22&RS=IN/%22Sharma;+Nigel%2201727nas a2200145   4500008004100000245007800041210006900119260000800188520105700196100002101253700002401274700002401298700002801322856023101350       2007                        eng d00aUnited {States} {Patent}: 7223371 - {Microfluidic} channel network device0 aUnited States Patent 7223371 Microfluidic channel network device  cmay3 aDescribed herein is microfluidic device for joining fluids and a related method for doing the same. The device according to the present invention includes a microfluidic junction, an outlet channel, and a plurality of circuit units. A microfluidic junction is an area for converging multiple fluids. An outlet channel is capable of receiving fluid from the microfluidic junction. An outlet channel includes a first end connected with the microfluidic junction, a second end connected with a waste reservoir, and an analysis region positioned between the first end and the second end of the outlet channel. The device also includes a plurality of circuit units. Each circuit unit includes a source channel with a first end capable of receiving sample fluid and a second end connected with the microfluidic junction; a branch channel connected with the source channel at an intersection; and a flow diversion system capable of differentially directing fluid flowing through a source channel either into the microfluidic junction or into a branch channel.1 aHayenga, Jon, W.1 aWeigl, Bernhard, H.1 aBardell, Ronald, L.1 aMorris, Christopher, J.  uhttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=15&f=G&l=50&co1=AND&d=PTXT&s1=%22Weigl%3B+Bernhard%22.INNM.&OS=IN/%22Weigl;+Bernhard%22&RS=IN/%22Weigl;+Bernhard%2201426nas a2200169   4500008004100000245014600041210006900187260000800256520063200264100002400896700002400920700002000944700002000964700002000984700002101004856023101025       2006                        eng d00aUnited {States} {Patent}: 7011791 - {Microfluidic} devices for rotational manipulation of the fluidic interface between multiple flow streams0 aUnited States Patent 7011791 Microfluidic devices for rotational  cmar3 aMicrofluidic devices and methods are provided for enhancing detection of a diffusion pattern formed by particles diffusing between at least two fluid streams in parallel laminar flow such that an interface is formed between them by increasing the dimension of the streams in the diffusion direction. This may be accomplished by flowing the streams through a transforming turn, or by flowing the streams through a channel having diverging walls. Devices and methods are also provided for enhancing diffusion between two streams comprising changing the interface between said streams from a narrow interface to a broad interface.1 aWeigl, Bernhard, H.1 aBardell, Ronald, L.1 aKamholz, Andrew1 aMunson, Matthew1 aSchilling, Eric1 aHawkins, Kenneth  uhttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=17&f=G&l=50&co1=AND&d=PTXT&s1=%22Weigl%3B+Bernhard%22.INNM.&OS=IN/%22Weigl;+Bernhard%22&RS=IN/%22Weigl;+Bernhard%2201057nas a2200157   4500008004100000245006500041210005600106260000800162520037900170100002400549700002600573700002100599700002400620700002400644856023100668       2004                        eng d00aUnited {States} {Patent}: 6743399 - {Pumpless} microfluidics0 aUnited States Patent 6743399 Pumpless microfluidics  cjun3 aA microfluidic device which operates without the need for an external power source. The device includes a body structure, at least one microscale channel within the structure, a port for introducing fluid into the channel, and a power source internal to the structure for propelling the fluid through the channel. Various structures are described which embody the invention.1 aWeigl, Bernhard, H.1 aWilliams, Clinton, L.1 aHayenga, Jon, W.1 aBardell, Ronald, L.1 aSchulte, Thomas, E.  uhttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=18&f=G&l=50&co1=AND&d=PTXT&s1=%22Weigl%3B+Bernhard%22.INNM.&OS=IN/%22Weigl;+Bernhard%22&RS=IN/%22Weigl;+Bernhard%2200985nas a2200145   4500008004100000245010200041210006900143260000800212520029400220100002400514700002200538700002400560700002400584856023100608       2003                        eng d00aUnited {States} {Patent}: 6557427 - {Capillaries} for fluid movement within microfluidic channels0 aUnited States Patent 6557427 Capillaries for fluid movement with  cmay3 aA capillary for introduction of whole blood into an analysis device. The capillary has a variable volume along its length, which allows the liquid sample to be drawn into the interior of the cartridge, away from the inlet, reducing the risk of contamination of the sample from the outside.1 aWeigl, Bernhard, H.1 aKlein, Gerald, L.1 aBardell, Ronald, L.1 aBattrell, Frederick  uhttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=22&f=G&l=50&co1=AND&d=PTXT&s1=%22Weigl%3B+Bernhard%22.INNM.&OS=IN/%22Weigl;+Bernhard%22&RS=IN/%22Weigl;+Bernhard%2200967nas a2200145   4500008004100000245007400041210006500115520029000180100002400470700002200494700002400516700002600540700002400566856023100590       2002                        eng d00aUnited {States} {Patent}: 6488896 - {Microfluidic} analysis cartridge0 aUnited States Patent 6488896 Microfluidic analysis cartridge3 aA device for analyzing sample solutions such as whole blood based on coagulation and agglutination which requires no external power source or moving parts to perform the analysis. Single disposable cartridges for performing blood typing assays can be constructed using this technology.1 aWeigl, Bernhard, H.1 aKlein, Gerald, L.1 aBardell, Ronald, L.1 aWilliams, Clinton, L.1 aSchulte, Thomas, H.  uhttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=24&f=G&l=50&co1=AND&d=PTXT&s1=%22Weigl%3B+Bernhard%22.INNM.&OS=IN/%22Weigl;+Bernhard%22&RS=IN/%22Weigl;+Bernhard%2201039nas a2200157   4500008004100000245007100041210006200112260000800174520035600182100002200538700002400560700002400584700002700608700002200635856022400657       1999                        eng d00aUnited {States} {Patent}: 5876187 - {Micropumps} with fixed valves0 aUnited States Patent 5876187 Micropumps with fixed valves  cmar3 aMicropumps fabricated by micromachining techniques and employing fixed or no-moving-parts valves. As one aspect of the invention, a laser-assisted chemical etching technique is employed for providing smooth-walled, curved configuration necessary to obtain the desired flow characteristics of the valves that are used in conjunction with the micropump.1 aForster, Fred, K.1 aBardell, Ronald, L.1 aBlanchard, Alan, P.1 aAfromowitz, Martin, A.1 aSharma, Nigel, R.  uhttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=4&f=G&l=50&co1=AND&d=PTXT&s1=%22Sharma%3B+Nigel%22.INNM.&OS=IN/%22Sharma;+Nigel%22&RS=IN/%22Sharma;+Nigel%22