@article {212,
	title = {A highly sensitive rapid diagnostic test for Chagas disease that utilizes a recombinant Trypanosoma cruzi antigen.},
	journal = {IEEE Trans Biomed Eng},
	volume = {58},
	year = {2011},
	month = {2011 Mar},
	pages = {814-7},
	abstract = {<p>Improved diagnostic tests for Chagas disease are urgently needed. A new lateral flow rapid test for Chagas disease is under development at PATH, in collaboration with Laboratorio Lemos of Argentina, which utilizes a recombinant antigen for detection of antibodies to Trypanosoma cruzi. To evaluate the performance of this test, 375 earlier characterized serum specimens from a region where Chagas is endemic were tested using a reference test (the Ortho T. cruzi ELISA, Johnson \& Johnson), a commercially available rapid test (Chagas STAT-PAK, Chembio), and the PATH-Lemos rapid test. Compared to the composite reference tests, the PATH-Lemos rapid test demonstrated an optimal sensitivity of 99.5\% and specificity of 96.8\%, while the Chagas STAT-PAK demonstrated a sensitivity of 95.3\% and specificity of 99.5\%. These results indicate that the PATH-Lemos rapid test shows promise as an improved and reliable tool for screening and diagnosis of Chagas disease.</p>},
	keywords = {Antibodies, Protozoan, Antigens, Protozoan, Chagas Disease, Humans, Immunoassay, Point-of-Care Systems, Recombinant Proteins, Sensitivity and Specificity, Trypanosoma cruzi},
	issn = {1558-2531},
	doi = {10.1109/TBME.2010.2087334},
	author = {Barfield, C A and Barney, R S and Crudder, C H and Wilmoth, J L and Stevens, D S and Mora-Garcia, S and Yanovsky, M J and Weigl, B H and Yanovsky, J}
}
