02245nas a2200325   4500008004100000022001400041245009000055210006900145260001300214300001100227490000600238520120000244653002601444653002801470653002801498653002601526653002501552653002201577653004201599653002101641653002201662653002101684653003401705653003701739653001101776653003001787100001901817700002301836856006001859       2014                        eng d  a1937-539500aMedical devices and diagnostics for cardiovascular diseases in low-resource settings.0 aMedical devices and diagnostics for cardiovascular diseases in l  c2014 Nov  a737-480 v73 a<p>Noncommunicable diseases (NCDs), including cardiovascular diseases and diabetes, have emerged as an underappreciated health threat with enormous economic and public health implications for populations in low-resource settings. In order to address these diseases, devices that are to be used in low-resource settings have to conform to requirements that are generally more challenging than those developed for traditional markets. Characteristics and issues that must be considered when working in low- and middle-income countries (LMICs) include challenging environmental conditions, a complex supply chain, sometimes inadequate operator training, and cost. Somewhat counterintuitively, devices for low-resource setting (LRS) markets need to be of at least as high quality and reliability as those for developed countries to be setting-appropriate and achieve impact. Finally, the devices need to be designed and tested for the populations in which they are to be used in order to achieve the performance that is needed. In this review, we focus on technologies for primary and secondary health-care settings and group them according to the continuum of care from prevention to treatment.</p>10aBiomedical Technology10aBlood Chemical Analysis10aCardiovascular Diseases10aCost-Benefit Analysis10aDeveloping Countries10aDiabetes Mellitus10aDiagnostic Techniques, Cardiovascular10aEquipment Design10aHealth Care Costs10aHealth Resources10aHealth Services Accessibility10aHealth Services Needs and Demand10aHumans10aPredictive Value of Tests1 aMcGuire, Helen1 aWeigl, Bernhard, H  uhttps://www.microfluidicsciences.com/drupal/?q=node/20101676nas a2200169   4500008004100000022001400041245014400055210006900199260001600268300001200284490000700296520108500303100002301388700001601411700001901427856006001446       2013                        ENG d  a2211-068200aPoint-of-Care Diagnostics in Low-Resource Settings and Their Impact on Care in the Age of the Noncommunicable and Chronic Disease Epidemic.0 aPointofCare Diagnostics in LowResource Settings and Their Impact  c2013 Dec 23  a248-2570 v193 a<p>The emergence of point-of-care (POC) diagnostics specifically designed for low-resource settings coupled with the rapid increase in need for routine care of patients with chronic diseases should prompt reconsideration of how health care can be delivered most beneficially and cost-effectively in developing countries. Bolstering support for primary care to provide rapid and appropriate integrated acute and chronic care treatment may be a possible solution. POC diagnostics can empower local and primary care providers and enable them to make better clinical decisions. This article explores the opportunity for POC diagnostics to strengthen primary care and chronic disease diagnosis and management in a low-resource setting (LRS) to deliver appropriate, consistent, and integrated care. We analyze the requirements of resource-appropriate chronic disease care, the characteristics of POC diagnostics in LRS versus the developed world, the many roles of diagnostics in the care continuum in LRS, and the process and economics of developing LRS-compatible POC diagnostics.</p>1 aWeigl, Bernhard, H1 aNeogi, Tina1 aMcGuire, Helen  uhttps://www.microfluidicsciences.com/drupal/?q=node/202