01666nas a2200289   4500008004100000022001400041245010800055210006900163260001500232300001100247490000700258520076600265653001201031653003201043653002701075653002401102653000901126653001301135653002601148653003001174653002501204653001201229100002501241700002401266700002701290856005901317       2004                        eng d  a0168-365900aIncreased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits.0 aIncreased accumulation of PEGPE micelles in the area of experime  c2004 Jan 8  a187-930 v943 a<p>Micelles prepared from polyethyleneglycol/phosphatidyl-ethanolamine conjugates (PEG-PE) with a size of 7-20 nm and zeta-potential of approximately -18 mV were administered i.v. to rabbits with experimental myocardial infarctions. Micelles demonstrated a prolonged circulation in the blood (half-life of 2 h) and accumulated in the infarction zone with efficiency more than 8-fold higher as compared to a non-damaged part of the heart muscle. Obtained results suggest that the enhanced permeability and retention (EPR) effect is the primary mechanism of accumulation of microparticles in the infarct areas, and that drug carriers such as PEG-PE micelles can be used for the delivery of therapeutic or diagnostic agents to an area of myocardial infarction.</p>10aAnimals10aArterial Occlusive Diseases10aDisease Models, Animal10aElectrocardiography10aMale10aMicelles10aMyocardial Infarction10aPhosphatidylethanolamines10aPolyethylene Glycols10aRabbits1 aLukyanov, Anatoly, N1 aHartner, William, C1 aTorchilin, Vladimir, P  uhttps://www.microfluidicsciences.com/drupal/?q=node/2101581nas a2200301   4500008004100000022001400041245006600055210006400121260000900185300001100194490000700205520074500212653001200957653001300969653001800982653001101000653001401011653000901025653002301034653002501057653001301082653002401095100002501119700002501144700002401169700002701193856005901220       2004                        eng d  a0920-506300aPEGylated dextran as long-circulating pharmaceutical carrier.0 aPEGylated dextran as longcirculating pharmaceutical carrier  c2004  a621-300 v153 a<p>Dextran-polyethylene glycol (PEG) conjugates were synthesized by activating dextran hydroxy groups with carbonyldiimidazole, introducing amino groups by attaching ethylenediamine, and reacting amino groups with a succinimidyl-activated derivative of PEG. Conjugates with an average of 12 and 21 PEG (5 kDa) residues per single dextran (73 kDa) molecule were prepared. These conjugates have circulation half-lives of 5.3 h and 7.0 h, respectively, compared to 4.0 h for non-PEGylated dextran. The modification of dextran with PEG inhibits the uptake of polymer by the major organ of the reticuloendothelial system, the liver. Dextran-PEG conjugates may represent a convenient platform for long-circulating pharmaceutical preparations.</p>10aAnimals10aDextrans10aDrug Carriers10aFemale10aHalf-Life10aMice10aMice, Inbred C57BL10aPolyethylene Glycols10aPolymers10aTissue Distribution1 aLukyanov, Anatoly, N1 aSawant, Rishikesh, M1 aHartner, William, C1 aTorchilin, Vladimir, P  uhttps://www.microfluidicsciences.com/drupal/?q=node/17