@patent {weigl_united_2002-2,
	title = {United {States} {Patent}: 6454945 - {Microfabricated} devices and methods},
	number = {6454945},
	year = {2002},
	month = {sep},
	abstract = {This invention provides microfabricated systems for extraction of desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact between the two streams is maintained for a sufficient period of time to allow differential transport of the desired particles from the sample stream into the extraction stream. In a preferred embodiment the differential transport mechanism is diffusion. The extraction system of this invention coupled to a microfabricated diffusion-based mixing device and/or sensing means allows picoliter quantities of fluid to be processed or analyzed on devices no larger than silicon wafers. Such diffusion-based mixing or sensing devices are preferably channel cell systems for detecting the presence and/or measuring the quantity of analyte particles in a sample stream.},
	url = {http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2\&Sect2=HITOFF\&p=1\&u=\%2Fnetahtml\%2FPTO\%2Fsearch-bool.html\&r=25\&f=G\&l=50\&co1=AND\&d=PTXT\&s1=\%22Weigl\%3B+Bernhard\%22.INNM.\&OS=IN/\%22Weigl;+Bernhard\%22\&RS=IN/\%22Weigl;+Bernhard\%22},
	author = {Weigl, Bernhard H. and Yager, Paul and Brody, James P. and Holl, Mark R. and Forster, Fred K. and Altendorf, Eric and Galambos, Paul C. and Kenny, Margaret and Schutte, David and Hixson, Gregory and Zebert, Diane and Kamholz, Andrew and Wu, Caicai}
}
@patent {weigl_united_2000-1,
	title = {United {States} {Patent}: 6159739 - {Device} and method for 3-dimensional alignment of particles in microfabricated flow channels},
	number = {6159739},
	year = {2000},
	month = {dec},
	abstract = {The present invention provides a sheath flow module made from a first plate of material having formed therein a laminar fluid flow channel; at least two inlets, each inlet joining the laminar flow channel at a junction, the first inlet junction being wider than the second inlet junction, and an outlet from the flow channel. A second plate, e.g. a transparent cover plate, seals the module and allows for optical measurements. A first inlet allows for introduction of a first fluid into the flow channel. The first fluid is the sheath fluid. A second inlet allows for introduction of a second fluid into the sheath fluid while it is flowing through the flow channel. The second fluid is the center fluid. Because the second inlet junction is narrower than the first inlet junction, the center fluid becomes surrounded on both sides by the sheath fluid. After all fluids have been introduced and sheath flow has been achieved, the depth of the flow channel can be decreased, leading to vertical hydrodynamic focusing. Optionally, the width of the flow channel can be decreased, leading to horizontal hydrodynamic focusing. The decrease in depth and width can be gradual or abrupt. The device of the present invention can function in two modes, the sheath flow mode and the particle injector mode, depending on the relative densities of the sheath fluid, the center fluid, and any particles in either fluid.},
	url = {http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2\&Sect2=HITOFF\&p=1\&u=\%2Fnetahtml\%2FPTO\%2Fsearch-bool.html\&r=31\&f=G\&l=50\&co1=AND\&d=PTXT\&s1=\%22Weigl\%3B+Bernhard\%22.INNM.\&OS=IN/\%22Weigl;+Bernhard\%22\&RS=IN/\%22Weigl;+Bernhard\%22},
	author = {Weigl, Bernhard and Yager, Paul and Brody, James P.}
}
@patent {weigl_united_1999-1,
	title = {United {States} {Patent}: 5972710 - {Microfabricated} diffusion-based chemical sensor},
	number = {5972710},
	year = {1999},
	month = {oct},
	abstract = {A channel-cell system is provided for detecting the presence and/or measuring the presence of analyte particles in a sample stream comprising: a) a laminar flow channel; b) two inlets in fluid connection with the laminar flow channel for respectively conducting into the laminar flow channel (1) an indicator stream which may comprise an indicator substance which indicates the presence of the analyte particles by a detectable change in property when contacted with the analyte particles, and (2) the sample stream; c) wherein the laminar flow channel has a depth sufficiently small to allow laminar flow of the streams and a length sufficient to allow particles of the analyte to diffuse into the indicator stream to the substantial exclusion of the larger particles in the sample stream to form a detection area; and d) an outlet for conducting the streams out of the laminar flow channel to form a single mixed stream.},
	url = {http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2\&Sect2=HITOFF\&p=1\&u=\%2Fnetahtml\%2FPTO\%2Fsearch-bool.html\&r=36\&f=G\&l=50\&co1=AND\&d=PTXT\&s1=\%22Weigl\%3B+Bernhard\%22.INNM.\&OS=IN/\%22Weigl;+Bernhard\%22\&RS=IN/\%22Weigl;+Bernhard\%22},
	author = {Weigl, Bernhard H. and Yager, Paul and Brody, James P. and Holl, Mark R. and Kenny, Margaret and Schutte, David and Hixson, Gregory and Zebert, M. Diane and Kamholz, Andrew and Wu, Caicai and Altendorf, Eric}
}
@patent {yager_united_1998,
	title = {United {States} {Patent}: 5716852 - {Microfabricated} diffusion-based chemical sensor},
	number = {5716852},
	year = {1998},
	month = {feb},
	abstract = {A channel-cell system is provided for detecting the presence and/or measuring the presence of analyte particles in a sample stream comprising: a) a laminar flow channel; b) two inlet means in fluid connection with said laminar flow channel for respectively conducting into said laminar flow channel (1) an indicator stream which may comprise an indicator substance which indicates the presence of said analyte particles by a detectable change in property when contacted with said analyte particles, and (2) said sample stream; c) wherein said laminar flow channel has a depth sufficiently small to allow laminar flow of said streams and a length sufficient to allow particles of said analyte to diffuse into said indicator stream to the substantial exclusion of said larger particles in said sample stream to form a detection area; and d) outlet means for conducting said streams out of said laminar flow channel to form a single mixed stream.},
	url = {http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2\&Sect2=HITOFF\&p=1\&u=\%2Fnetahtml\%2FPTO\%2Fsearch-bool.html\&r=39\&f=G\&l=50\&co1=AND\&d=PTXT\&s1=\%22Weigl\%3B+Bernhard\%22.INNM.\&OS=IN/\%22Weigl;+Bernhard\%22\&RS=IN/\%22Weigl;+Bernhard\%22},
	author = {Yager, Paul and Weigl, Bernhard H. and Brody, James P. and Holl, Mark R.}
}
