01665nas a2200289   4500008004100000022001400041245010800055210006900163260001500232300001100247490000700258520076600265653001201031653003201043653002701075653002401102653000901126653001301135653002601148653003001174653002501204653001201229100002501241700002401266700002701290856005801317       2004                        eng d  a0168-365900aIncreased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits.0 aIncreased accumulation of PEGPE micelles in the area of experime  c2004 Jan 8  a187-930 v943 a<p>Micelles prepared from polyethyleneglycol/phosphatidyl-ethanolamine conjugates (PEG-PE) with a size of 7-20 nm and zeta-potential of approximately -18 mV were administered i.v. to rabbits with experimental myocardial infarctions. Micelles demonstrated a prolonged circulation in the blood (half-life of 2 h) and accumulated in the infarction zone with efficiency more than 8-fold higher as compared to a non-damaged part of the heart muscle. Obtained results suggest that the enhanced permeability and retention (EPR) effect is the primary mechanism of accumulation of microparticles in the infarct areas, and that drug carriers such as PEG-PE micelles can be used for the delivery of therapeutic or diagnostic agents to an area of myocardial infarction.</p>10aAnimals10aArterial Occlusive Diseases10aDisease Models, Animal10aElectrocardiography10aMale10aMicelles10aMyocardial Infarction10aPhosphatidylethanolamines10aPolyethylene Glycols10aRabbits1 aLukyanov, Anatoly, N1 aHartner, William, C1 aTorchilin, Vladimir, P  uhttp://www.microfluidicsciences.com/drupal/?q=node/21