02037nas a2200337   4500008004100000022001400041245010800055210006900163260001500232300001200247490000700259520105900266653001201325653001501337653002601352653003001378653001801408653001901426653001101445653001301456653001401469653003001483653002501513653001301538653001301551653001501564653001001579100002501589700002701614856005801641       2004                        eng d  a0169-409X00aMicelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs.0 aMicelles from lipid derivatives of watersoluble polymers as deli  c2004 May 7  a1273-890 v563 a<p>Polymeric micelles have a whole set of unique characteristics, which make them very promising drug carriers, in particular, for poorly soluble drugs. Our review article focuses on micelles prepared from conjugates of water-soluble polymers, such as polyethylene glycol (PEG) or polyvinyl pyrrolidone (PVP), with phospholipids or long-chain fatty acids. The preparation of micelles from certain polymer-lipid conjugates and the loading of these micelles with various poorly soluble anticancer agents are discussed. The data on the characterization of micellar preparations in terms of their morphology, stability, longevity in circulation, and ability to spontaneously accumulate in experimental tumors via the enhanced permeability and retention (EPR) effect are presented. The review also considers the preparation of targeted immunomicelles with specific antibodies attached to their surface. Available in vivo results on the efficiency of anticancer drugs incorporated into plain micelles and immunomicelles in animal models are also discussed.</p>10aAnimals10aAntibodies10aAntineoplastic Agents10aChemistry, Pharmaceutical10aDrug Carriers10aDrug Stability10aLipids10aMicelles10aNeoplasms10aPhosphatidylethanolamines10aPolyethylene Glycols10aPolymers10aPovidone10aSolubility10aWater1 aLukyanov, Anatoly, N1 aTorchilin, Vladimir, P  uhttp://www.microfluidicsciences.com/drupal/?q=node/18